PathwayStep379 PathwayStep371 PathwayStep360 PathwayStep365 PathwayStep353 Stabilization of mRNA by HuR Destabilization of mRNA by Tristetraprolin (TTP) Destabilization of mRNA by KSRP Destabilization of mRNA by AUF1 (hnRNP D0) Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) Regulation of mRNA Stability by Proteins that Bind AU-rich Elements Authored: May, B, 2009-12-29 Edited: May, B, 2009-12-29 Pubmed12440953 Pubmed12704645 Pubmed15460540 Pubmed16391004 RNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-element binding proteins is regulated, usually by phosphorylation but also by subcellular localization. Reactome Database ID Release 43450531 Reactome, http://www.reactome.org ReactomeREACT_24994 Reviewed: Wilusz, J, 2010-06-29