Removal of aminoterminal propeptides from gamma-carboxylated proteins Authored: D'Eustachio, P, 2005-03-17 16:24:57 Edited: D'Eustachio, P, 0000-00-00 00:00:00 Furin is an endopeptidase localized to the Golgi membrane that cleaves many proteins on the carboxyterminal side of the sequence motif Arg-[any residue]-(Lys or Arg)-Arg (Jones et al. 1995; Leduc et al. 1992). In the case of gamma-carboxylated proteins, if this cleavage does not occur, the proteins are still secreted but do not function properly (Bristol et al. 1993; Lind et al. 1997). The aminoterminal fragments, "propeptides", generated in this reaction have no known function; the carboxylated, cleaved proteins are delivered to the cell membrane or secreted from the cell via pathways to be annotated in a future release of Reactome. GENE ONTOLOGYGO:0006508 Pubmed1629222 Pubmed8463288 Pubmed8846780 Pubmed9108399 Reactome Database ID Release 43159782 Reactome, http://www.reactome.org ReactomeREACT_733 PathwayStep3070 PathwayStep3065 PathwayStep3064 PathwayStep3063 PathwayStep3069 PathwayStep3068 PathwayStep3067 PathwayStep3066 pro-protein C -> protein C + protein C propeptide pro-protein S -> protein S + protein S propeptide pro-protein Z -> protein Z + protein Z propeptide pro-GAS6 -> GAS6 + GAS6 propeptide pro-factor VII -> factor VII + factor VII propeptide pro-factor IX -> factor IX + factor IX propeptide pro-prothrombin -> prothrombin + prothrombin propeptide pro-factor X -> factor X + factor X propeptide