The activation of arylsulfatases Hypusinylation PTM: gamma carboxylation, hypusine formation and arylsulfatase activation After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the vitamin K-dependent attachment of carboxyl groups to glutamate residues and the conversion of lysine residues to hypusine. Authored: D'Eustachio, P, 2005-05-07 21:32:05 Edited: D'Eustachio, P, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0043687 Reactome Database ID Release 43163841 Reactome, http://www.reactome.org ReactomeREACT_1069 Reviewed: Orlean, P, Stafford, DW, 0000-00-00 00:00:00 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins PathwayStep3076 PathwayStep3078 PathwayStep3072