Removal of aminoterminal propeptides from gamma-carboxylated proteins Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Gamma-carboxylation of protein precursors Gamma-carboxylation, transport, and amino-terminal cleavage of proteins A number of proteins, including eight required for normal blood clot formation and its regulation (Prothrombin (factor II), factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas6) share a sequence motif rich in glutamate residues near their amino termini. Carboxylation of the glutamate residues within this motif followed by removal of an aminoterminal propeptide is required for each of these proteins to function. These modifications occur as the proteins move through the endoplasmic reticulum and Golgi apparatus. Authored: D'Eustachio, P, 2005-03-17 16:24:57 Edited: D'Eustachio, P, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0017187 Reactome Database ID Release 43159854 Reactome, http://www.reactome.org ReactomeREACT_1132 Reviewed: Stafford, DW, 0000-00-00 00:00:00 PathwayStep3053 PathwayStep3044 PathwayStep3071 PathwayStep3062 vitamin K epoxide -> vitamin K hydroquinone