Calnexin/calreticulin cycle Authored: Dall'Olio, GM, 2009-11-10 Edited: Jassal, B, 2010-07-02 Pubmed18303019 Pubmed18337472 Reactome Database ID Release 43901042 Reactome, http://www.reactome.org ReactomeREACT_23810 Reviewed: Gagneux, P, 2010-08-17 The unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and Parodi AJ, 2008), but in certain cases can occur even in the absence of glycosylation (Ireland BS et al, 2008). ER Quality Control Compartment (ERQC) PathwayStep3135 PathwayStep3134 PathwayStep3145 PathwayStep3137 PathwayStep3136 Binding of calnexin/calreticulin to the unfolded protein Removal of the third glucose by glucosidase II and release from the chaperone Binding of ERp57 Incorrectly folded glycoproteins translocate to the ERQC