Synthesis of GDP-mannose Authored: Dall'Olio, GM, 2009-11-10 Edited: Jassal, B, 2009-11-10 GDP-mannose is the mannose donor for the first 5 mannose addition reactions in the N-glycan precursor synthesis, and also for the synthesis of Dolichyl-phosphate-mannose involved in other mannose transfer reactions. It is synthesized from fructose 6-phosphate and GTP in three steps. GENE ONTOLOGYGO:0009298 Reactome Database ID Release 43446205 Reactome, http://www.reactome.org ReactomeREACT_22423 Reviewed: Gagneux, P, 2010-04-16 PathwayStep3109 PathwayStep3107 PathwayStep3108 Mannose-1-phosphate converted to GDP-Mannose Fructose 6-phosphate isomerizes to Mannose 6-phosphate Mannose 6-phosphate isomerizes to Mannose 1-phosphate