Synthesis of Dolichyl-phosphate Authored: Dall'Olio, GM, 2009-11-10 Dolichol is a polyisoprenol lipid comprised of five-carbon isoprene units linked linearly in a head-to-tail fashion. In the N-glycan biosynthesis pathway, dolichyl phosphate is used as an anchor for the N-glycan sugar to the ER membrane, and as an initiation point for the synthesis. Dolichyl phosphate can be obtained either from direct phosphorylation of dolichol or from de-phosphorylation of dolichyl diphosphate, released at the end of the N-glycan biosynthesis pathway. Edited: Jassal, B, 2009-11-10 GENE ONTOLOGYGO:0006489 Reactome Database ID Release 43446199 Reactome, http://www.reactome.org ReactomeREACT_22230 Reviewed: Gagneux, P, 2010-04-16 PathwayStep3099 PathwayStep3100 Phosphorylation of dolichol Dephosphorylation of dolichyl diphosphate