PathwayStep2991 PathwayStep2990 Gap-filling DNA repair synthesis and ligation in GG-NER Authored: Gopinathrao, G, 2004-02-02 17:30:34 GENE ONTOLOGYGO:0006297 Pubmed9111189 Reactome Database ID Release 4374969 Reactome, http://www.reactome.org ReactomeREACT_1998 The resultant gap is filled by polymerase activities of Pol delta and Pol epsilon. Accessory replication protein complexes of RPA, PCNA and RFC play a role in this synthesis. DNA Ligase 1 seals the gap restoring the covalent integrity of the repaired strand.<BR> Repair synthesis of patch ~27-30 bases long by DNA polymerase Ligation of newly synthesized repair patch to incised DNA in GG-NER