PathwayStep2997 Gap-filling DNA repair synthesis and ligation in TC-NER Transcription-coupled NER (TC-NER) Authored: Joshi-Tope, G, 2003-07-14 15:01:00 GENE ONTOLOGYGO:0006283 Pubmed11823795 Pubmed3466163 Reactome Database ID Release 4373937 Reactome, http://www.reactome.org ReactomeREACT_1628 The preferential repair of UV-induced damage in transcribed strands of active genes is known as Transcription-coupled NER (TC-NER). Impairment of the ability for TC-NER results in the onset of a severe hereditary disorder called Cockayne’s syndrome, an autosomal recessive disease characterized by hypersensitivity to UV light . Many types of helix distorting lesions can block the movement of elongating RNA Pol II leading to its stalling and subsequent triggering of repair mechanisms. The repair of DNA damage in active genes occurs much faster compared to the repair in non-transcribed genomic regions (via GG-NER). Also, the non-transcribed strand of the same gene is repaired at a similar rate as that of non-transcribed genomic regions.<BR>The transcriptional responses to DNA damage in terms of stalling of Pol II, its displacement from the lesion site etc. are not well elucidated. The following annotation in GK provides an overall picture of TC-NER and will be updated as and when new insights are obtained about these crucial steps.<BR> Dual incision reaction in TC-NER Formation of transcription-coupled NER (TC-NER) repair complex PathwayStep3006 PathwayStep3007 PathwayStep3001 Resumption of transcription after TC-NER