Formation of tubulin folding intermediates by CCT/TriC Authored: Matthews, L, 2008-12-01 04:46:41 Edited: Matthews, L, 2009-02-21 04:38:35 GENE ONTOLOGYGO:0006457 Pubmed11868281 Pubmed1361170 Pubmed8096061 Pubmed9265649 Reactome Database ID Release 43389960 Reactome, http://www.reactome.org ReactomeREACT_16956 Reviewed: Cowan, NJ, 2009-01-21 16:47:24 TriC/CCT forms a binary complex with unfolded alpha- or beta-tubulin (Frydman et al., 1992; Gao et al., 1993). The tubulin folding intermediates produced by TriC are unstable (Gao et al., 1993). Five additional protein cofactors (cofactor A-E) are required for the generation of properly folded alpha- and beta-tubulin and for the formation of alpha/beta-tubulin heterodimers (Gao et al., 1993) (Tian et al., 1997, Cowan and Lewis 2001). PathwayStep3022 PathwayStep3023 Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex