PathwayStep1704 Acetylcholine clearance from synaptic cleft Neurotransmitter Clearance In The Synaptic Cleft Authored: Mahajan, SS, 2008-01-14 16:01:52 Edited: Mahajan, SS, 2008-01-14 16:01:52 GENE ONTOLOGYGO:0042136 Neurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synaptic cell. The neurotransmitter is cleared by either re-uptake by the pre-synaptic neuron, diffusion in the perisynaptic area, uptake by astrocytes surrounding the synaptic cleft or enzymatic degradation of the neurotransmitter.<BR>This topic will be annotated in a future release. Reactome Database ID Release 43112311 Reactome, http://www.reactome.org ReactomeREACT_13583 Reviewed: Restituito, S, 2008-11-27 12:38:49 Clearance of seratonin Clearance of dopamine PathwayStep3291 PathwayStep3279 PathwayStep3287 Noradrenaline clearance from the synaptic cleft