PathwayStep1708 Synthesis of o-acetylcholine Acetylcholine Neurotransmitter Release Cycle Acetylcholine neurotransmitter release cycle involves syntheis of choline, loading of clathrin scultpted synaptic vesicles, docking and priming of the acetyl choline loaded synaptic vesicles and then release of acetylcholine. This cycle occurs in neurons of central nervous system (CNS), peripheral, autonomic and somatic nervous system. In the CNS, the acetylcholine is released by the presynaptic neurons into the synaptic cleft where the released acetylcholine is accessible to acetylcholine receptors located on the postsynaptic neurons. Authored: Mahajan, SS, 2008-01-14 16:01:52 Edited: Mahajan, SS, 2008-11-18 00:03:09 Pubmed18029057 Reactome Database ID Release 43264642 Reactome, http://www.reactome.org ReactomeREACT_15309 Reviewed: Kavalali, E, 2008-04-24 16:31:34 PathwayStep3260 PathwayStep3261 PathwayStep3262 PathwayStep3263 PathwayStep3264 Re-acidification of the clathrin sculpted acetylcholine transport vesicle Transport of Choline Loading of acetylcholine in synaptic vesicle Acetylcholine synaptic vesicle docking and priming Release of acetylcholine at the synapse