GABA synthesis Authored: Mahajan, SS, 2010-06-29 Edited: Mahajan, SS, 2010-06-29 GABA synthesized uniquely by two forms of glutamate decarboxylases, GAD65 and GAD67, that are functionally distinct and have different co-factor requirements. GAD65 is functionally linked to VGAT, the GABA transporter and selectively GABA synthesized by GAD65 is preferably loaded into the synaptic vesicles. GABA synthesized by GAD67 may be used for functions other than nuerotransmission. Pubmed12467378 Pubmed9777630 Pubmed9871412 Reactome Database ID Release 43888568 Reactome, http://www.reactome.org ReactomeREACT_24020 Reviewed: Restituito, S, 2008-11-27 12:38:49 PathwayStep3266 PathwayStep3267 Synthesis of GABA by GAD1 Synthesis of GABA by GAD2