Serotonin Neurotransmitter Release Cycle Authored: Mahajan, SS, 2008-01-14 16:01:52 Edited: Mahajan, SS, 2008-11-18 00:03:09 Reactome Database ID Release 43181429 Reactome, http://www.reactome.org ReactomeREACT_15425 Reviewed: Kavalali, E, 2008-04-24 16:31:34 Serotonin is synthesized in the serotonergic neurons in the central nervous system and the enterochrommaffin cells of the gastroinetstinal system. Serotonin is loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and release after the change in the membrane potential that activates voltage gated calcium channels and the reponse by several proetins to the changes in intracellular Ca2+ increase leads to fusion of the vesicle and release of serotonin into the synapse. PathwayStep3246 PathwayStep3247 PathwayStep3238 PathwayStep3245 Release of docked serotonin loaded synaptic vesicle Serotonin loaded synaptic vesicle docking and priming Re-acidification of clathrin sculpted monoamine tranport vesicle lumen loading of Serotonin in synaptic vesicles