COPII (Coat Protein 2) Mediated Vesicle Transport Authored: Gillespie, ME, 2007-07-13 20:42:29 COPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the Golgi apparatus. COPII-coated vesicles were originally discovered in the yeast Saccharomyces cerevisiae using genetic approaches coupled with a cell-free assay. The mammalian counterpart of this pathway is represented here. Newly synthesized proteins destined for secretion are sorted into COPII-coated vesicles at specialized regions of the ER. These vesicles leave the ER, become uncoated and subsequently fuse with the Golgi apparatus membrane. Edited: Gillespie, ME, 2007-11-21 20:48:45 GENE ONTOLOGYGO:0048208 Pubmed11252894 Pubmed17316621 Reactome Database ID Release 43204005 Reactome, http://www.reactome.org ReactomeREACT_12507 Reviewed: Gagneux, P, 2010-11-18 PathwayStep3152 PathwayStep3153 PathwayStep3150 PathwayStep3151 PathwayStep3154 PathwayStep3155 Sar1p Activation And Membrane Binding Vesicle Uncoating Loss of Sar1b GTPase Coat Assembly Vesicle Budding Cargo, Sec31p:Sec13p, and v-SNARE recruitment