Reactions specific to the complex N-glycan synthesis pathway Authored: Dall'Olio, GM, 2009-11-10 Edited: Jassal, B, 2010-09-30 If MAN2 acts before MGAT3, the pathway progresses to complex N-glycans, because MAN2 is not able to operate on bisected oligosaccharides (11421343, page 5). The expression of MAN2 over MGAT3 in a tissue can regulate the synthesis of hybrid or complex N-glycans. Reactome Database ID Release 43975578 Reactome, http://www.reactome.org ReactomeREACT_25302 Reviewed: Gagneux, P, 2010-11-18 PathwayStep3169 PathwayStep3167 PathwayStep3168 Addition of alpha 1,6 fucose to the first GlcNAc of the N-glycan Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 Trimming of mannoses on the alpha1,6 arm by MAN2A1