Termination of O-glycan biosynthesis Authored: Jassal, B, 2010-10-15 Edited: Jassal, B, 2010-10-15 GENE ONTOLOGYGO:0016266 O-glycan biosynthesis can be terminated (or modified) by the addition of sialic acid residues on Core 1 and 2 glycoproteins by sialyltransferases (Varki et al, 2009). Pubmed20301246 Reactome Database ID Release 43977068 Reactome, http://www.reactome.org ReactomeREACT_115835 Reviewed: Ferrer, A, 2011-11-04 PathwayStep3191 PathwayStep3193 PathwayStep3192 PathwayStep3195 PathwayStep3194 ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position