Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Authored: Mahajan, SS, 2010-11-08 Edited: D'Eustachio, P, 2010-11-24 GABA B receptors are coupled to Gproteins and function by increasing the K+ and decreasing the Ca2+ inside the cell. The increase in K+ increases the negative membrane potential of the cell thereby hyper polarizing the cell which inhibits the release of neurotransmitters. The decrease in Ca2+ also inhibits neurotransmitter in two ways; first by preventing the fusion of synaptic vesicles containing the neurotransmitter with the plasma membrane and second by decreasing the Ca2+ dependent recruitment of synaptic vesicles to the plasma membrane. In particular GABA B receptors inhibit voltage gated Ca2+ channels via the activity of Gbeta/Ggamma subunits of G proteins. Pubmed20655481 Pubmed20655490 Reactome Database ID Release 43997272 Reactome, http://www.reactome.org ReactomeREACT_25004 Reviewed: Restituito, S, 2008-11-27 12:38:49 PathwayStep3376 Activation of GIRK/Kir3 Channels