G protein gated Potassium channels Authored: Mahajan, SS, 2011-05-18 Edited: Mahajan, SS, 2011-05-23 Inwardly rectifying G protein activated K+ channels (GIRK) are tetrameric assemblies of Ki3 3 family subunits (Kir 3.1, 3.2 3.3 and 3.4). The activation of G protein coupled receptor by ligand results in the liberation of G alpha and G beta gamma subunits. Gbeta gamma subunits interact and activate GIRK channels. Pubmed20921230 Reactome Database ID Release 431296059 Reactome, http://www.reactome.org ReactomeREACT_75780 Reviewed: Jassal, B, 2010-09-23 Activation of G protein gated Potassium channels PathwayStep3392