GABA B receptor activation Authored: Mahajan, SS, 2010-11-08 Edited: D'Eustachio, P, 2010-11-24 Functional GABA B receptors are heteromers of GABA B1 and B2 subunits, complexed with G protein alpha-i, 0, beta, and gamma subunits. They function as metabotropic receptors. When GABA is bound to the B1 sub-unit, the B2 subunit undergoes a conformational change that releases the G alpha-i G0 dimer (which binds and inactivates cytosolic adenylate cyclase) and the G beta G gamma dimer (which activates the GIRK (KIR3) potassium channel) (Pinard et al. 2010). Pubmed20655485 Reactome Database ID Release 43977444 Reactome, http://www.reactome.org ReactomeREACT_25031 Reviewed: Restituito, S, 2008-11-27 12:38:49 Activation of GABAB receptors PathwayStep3378 PathwayStep3368 GABAB heterodimeric receptor binds GABA