GABA A (rho) receptor activation GABA B receptor activation GABA receptor activation Authored: Mahajan, SS, 2010-11-08 Edited: D'Eustachio, P, 2010-11-24 Gamma aminobutyric acid (GABA) receptors are the major inhibitory receptors in human synapses. They are of two types. GABA A receptors are fast-acting ligand gated chloride ion channels that mediate membrane depolarization and thus inhibit neurotransmitter release (G Michels et al Crit Rev Biochem Mol Biol 42, 2007, 3-14). GABA B receptors are slow acting metabotropic Gprotein coupled receptors that act via the inhibitory action of their Galpha/Go subunits on adenylate cyclase to attenuate the actions of PKA. In addition, their Gbeta/gamma subunits interact directly with N and P/Q Ca2+ channels to decrease the release of Ca2+. GABA B receptors also interact with Kir3 K+ channels and increase the influx of K+, leading to cell membrane hyperpolarization and inhibition of channels such as NMDA receptors (A Pinard et al Adv Pharmacol, 58, 2010, 231-55). Pubmed11283747 Pubmed15269338 Pubmed17364682 Pubmed20655481 Pubmed20655485 Reactome Database ID Release 43977443 Reactome, http://www.reactome.org ReactomeREACT_25199 Reviewed: Restituito, S, 2008-11-27 12:38:49 GABA A receptor activation PathwayStep3379 PathwayStep3381 PathwayStep3367