GABA A receptor activation Authored: Mahajan, SS, 2010-11-08 Edited: D'Eustachio, P, 2010-11-24 GABA B receptors are G protein coupled receptors that are activated by GABA binding to the B1 subunit and B2 subunit alters the activity of adenylate cyclase by interacting with the G alpha i/alpha 0 subunit of the pertussis toxin sensitive G protein. The activation of GABA B receptors results in the inhibition of adenylate cyclase activity decreasing the levels of cyclic AMP production and hence the activity of Protein kinase A. Pubmed17364682 Pubmed18382465 Pubmed19828786 Reactome Database ID Release 43977441 Reactome, http://www.reactome.org ReactomeREACT_24987 Reviewed: Restituito, S, 2008-11-27 12:38:49 PathwayStep3366 The GABA(A) receptor complex is permeable to Cl- when GABA binds to it