Adenylate cyclase inhibitory pathway Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 GENE ONTOLOGYGO:0007193 Guanine nucleotide-binding protein G(i) alpha (Gi-alpha) inhibits adenylate cyclase, thus inhibiting the production of cAMP from ATP and ultimately decreasing the activity of cAMP-dependent protein kinase. Pubmed14993377 Reactome Database ID Release 43170670 Reactome, http://www.reactome.org ReactomeREACT_15333 Reviewed: Castagnoli, L, 2008-11-06 12:55:54 PathwayStep3369 PathwayStep3373 PathwayStep3372 PathwayStep3371 PathwayStep3370 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex G alpha (i) inhibits adenylate cyclase Adenylate cyclase increases the GTPase activity of Gi alpha Adenylate cyclase increases the GTPase activity of G alpha-olf Dissociation of the Gi alpha:G olf complex