Post NMDA receptor activation events Authored: Mahajan, SS, 2009-10-29 Ca2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca2+ within the spine leads to phosphorylation of Cyclic AMP Response Element binding protein (CREB) at serine 133 which is involved in the transcription of genes that results in long lasting changes in the synapse. The phosphorylation of CREB by increased Ca2+ can be brought about by distinct molecular pathways that may involve MAP kinase, activation of adenylate cyclase, activation of CaMKII and/or the activation of CaMKIV. Pubmed18616423 Reactome Database ID Release 43438064 Reactome, http://www.reactome.org ReactomeREACT_20593 Reviewed: Tukey, D, 2009-11-17 CREB phosphorylation through the activation of Ras CREB phosphorylation through the activation of CaMKK CREB phosphorylation through the activation of Adenylate Cyclase CREB phosphorylation through the activation of CaMKII PathwayStep3345 PathwayStep3352 PathwayStep3337 PathwayStep3340