CREB phosphorylation through the activation of Ras Authored: Mahajan, SS, 2009-10-29 Ca2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca2+ within the spine leads to phosphorylation of Cyclic AMP Response Element binding protein (CREB) at serine 133 which is involved in the transcription of genes that results in long lasting changes in the synapse. The phosphorylation of CREB by increased Ca2+ can be brought about by distinct molecular pathways that may involve MAP kinase, activation of adenylate cyclase, activation of CaMKII and/or the activation of CaMKIV. Edited: Gillespie, ME, 2009-11-19 Pubmed12819448 Reactome Database ID Release 43442742 Reactome, http://www.reactome.org ReactomeREACT_20568 Reviewed: Tukey, D, 2009-11-17 Ras activation uopn Ca2+ infux through NMDA receptor RSK activation PathwayStep3330 PathwayStep3331 PathwayStep3332 PathwayStep3335 PathwayStep3336 Phosphorylation of CREB by ribosomal protein S6 kinase Raf activation Activation of MAPK