CREB phosphorylation through the activation of CaMKK Authored: Mahajan, SS, 2009-10-29 Edited: Gillespie, ME, 2009-11-19 Pubmed18817731 Reactome Database ID Release 43442717 Reactome, http://www.reactome.org ReactomeREACT_20661 Reviewed: Tukey, D, 2009-11-17 Transient increase in intracellular Ca2+ concentration after NMDA receptor activation leads to the activation of the CaMKIV via the activation of CaM-kinase kinase. CaM-kinase kinase and CaMKIV are both activated upon binding Ca2+/Calmodulin after Ca2+ influx through activated NMDA receptor. Activation of CaMK IV PathwayStep3346 PathwayStep3351 PathwayStep3350 Activation of CaMKK Phosphorylation of CREB by CaMKIV