CREB phosphorylation through the activation of Adenylate Cyclase Authored: Mahajan, SS, 2009-10-29 Ca2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-induced transcription. The isoforms of adenylate cyclase that are activated by Ca2+ in the brain are I, III and IX. Edited: Gillespie, ME, 2009-11-19 Pubmed19244110 Reactome Database ID Release 43442720 Reactome, http://www.reactome.org ReactomeREACT_20625 Reviewed: Tukey, D, 2009-11-17 PathwayStep3338 PathwayStep3339 Phosphorylation of CREB by PKA Activation of Adenylate Cyclase