AMPK-alpha2 Phosphorylates TBC1D1 Authored: May, B, 2011-07-15 EC Number: 2.7.11 Edited: May, B, 2011-07-15 In response to muscle contraction and insulin signaling, AMPK-alpha2 phosphorylates TBC1D1 on serine 237 and probably other residues (Frosig et al. 2010, Vichaiwong et al. 2010). As inferred from rat L6 muscle cells TBC1D1 colocalizes with perinuclear vesicles bearing GLUT4 and may be involved in an early step that mobilizes them (Chen et al. 2008). Human TBC1D1 appears cytosolic and is believed to be concentrated near vesicle membranes (Park et al. 2011). Pubmed17995453 Pubmed20701589 Pubmed20837646 Pubmed21454505 Reactome Database ID Release 431454699 Reactome, http://www.reactome.org ReactomeREACT_147871 Reviewed: Klip, Amira, 2012-08-21