CHMP2 CHMP4 Ubiquinated and PIP3 Endosmal Membrane Bound Cargo ESCRT-III/Cargo Complex ESCRT Disassembly Authored: Gillespie, ME, 2010-08-10 Disassembly Phase <br> The AAA-ATPase, Vps4 disassembles ESCRT-III and catalyzes the final step of the MVB pathway. The microtubule interacting and trafficking (MIT) domain of Vps4 interacts directly with the C-terminal region of Vps2 (MIM1) and Vps20 (MIM2). The association of Vta1, which contains two MIT domains, greatly enhances the activity of Vps4. Please note that the recomended names of the Vacuolar protein sorting-associated proteins (Vps) are Charged multivesicular body proteins or CHMPs. EC Number: 3.6.1.3 Edited: Gillespie, ME, 2010-08-10 Pubmed11563910 Pubmed15075231 Pubmed19345195 Reactome Database ID Release 43917693 Reactome, http://www.reactome.org ReactomeREACT_27184 Reviewed: Rush, MG, 2008-01-11 00:00:00