Junctional channel Hemi-channels Formation of junctional channels Authored: Gilleron, J, Segretain, D, Falk, MM, 2007-01-03 12:23:09 Edited: Matthews, L, 2007-04-12 12:57:50 Junctional channels are an assembly of two docked connexons on adjacent cells that permits direct communication of the cytoplasm in the two cells as shown below. Proteins associated with GJs such as catenins (Wu et al., 2003, Shaw et al., 2007) and L-CAM (Musil et al., 1990) might be required for connexon docking. Docking occurs through a tight interaction of the extracellular loops (Unger et al., 1999; Sosinsky and Nicholson, 2005). Intramolecular disulfide bridges between the two extracellular loops (E1 and E2) of connexin polypeptides are important for the correct three-dimensional structure of the extracellular loops (Foote et al., 1998) Pubmed10024245 Pubmed12577316 Pubmed15925321 Pubmed1850831 Pubmed2172261 Pubmed9490731 Reactome Database ID Release 43190788 Reactome, http://www.reactome.org ReactomeREACT_9990 has a Stoichiometric coefficient of 2