RALA:GTP:MYO1C:Exocyst RALA:GTP:MYO1C:Calmodulin:F-actin Translocation of GLUT4 Vesicle and Docking at the Plasma Membrane As inferred from mouse, GLUT4 initially translocates from endosomes to insulin-responsive vesicles (IRVs, GSVs). RAB11 appears to play a role in this process. IRVs bearing GLUT4 are then translocated across the cortical actin network to the plasma membrane. Myosins 2A, 2B, 5A, and 5B contribute to translocation and are presumed to be involved in this step. Myosin 1C appears to act close to the plasma membrane and may facilitate fusion of the vesicle with the plasma membrane. RAB:GTP complexes coupled to the vesicles may interact with myosins to regulate their activity. Authored: May, B, 2012-05-27 Edited: May, B, 2012-05-27 Reactome Database ID Release 432316352 Reactome, http://www.reactome.org ReactomeREACT_147776 Reviewed: Klip, Amira, 2012-08-21 Exocyst Complex