Neurofascin:Ankyrin-G complex Neurofascin binds Ankyrin-G Authored: Garapati, P V, 2008-07-30 10:22:58 Edited: Garapati, P V, 2008-07-30 10:22:58 Pubmed9804856 Reactome Database ID Release 43373729 Reactome, http://www.reactome.org ReactomeREACT_22341 Reviewed: Maness, PF, 2010-02-16 The cytoplasmic domains of neurofascin contains a highly conserved sequence (F1315IGQY) that binds ankyrin. The membrane binding domain of ankyrin has two distinct binding sites for neurofascin and is proposed to form lateral complexes between ion channels and cell adhesion molecules as well as to couple these proteins to the spectrin based membrane skeleton.