CHL1:CNTN6 CHL1 interacts with contactin-6 Authored: Garapati, P V, 2008-07-30 10:22:58 Close homolog of L1 (CHL1), associates with Contactin-6/NB-3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. CHL1 and NB3 may engage in a cis-interaction and form a coreceptor/adhesion complex on the neuronal surface.<br>CHL1/NB3 clustering activates protein tyrosine phosphatase alpha (PTP alpha), which dephosphorylates and activates Fyn. Both PTP alpha and Fyn are required for proper apical dendrite orientation of deep layer pyramidal neurons. Edited: Garapati, P V, 2008-07-30 10:22:58 Pubmed18760361 Reactome Database ID Release 43443782 Reactome, http://www.reactome.org ReactomeREACT_22372 Reviewed: Maness, PF, 2010-02-16