SMAD2/3 p-2S-SMAD2/3 Phosphorylation of R-SMAD2/3 by NODAL Receptor Authored: May, B, 2011-01-27 EC Number: 2.7.11 Edited: May, B, 2011-01-27 NODAL receptors signal by phosphorylating SMAD2 and SMAD3 (Bondestam et al. 2001, Kumar et al. 2001, DaCosta Byfield et al. 2004). As in TGF-beta signaling, Smad anchor for receptor activation (SARA) may bind and present SMAD2 and SMAD3 for phosphorylation but this has not yet been demonstrated in NODAL signaling. Pubmed11024047 Pubmed12063393 Pubmed14978253 Reactome Database ID Release 431181355 Reactome, http://www.reactome.org ReactomeREACT_111138 Reviewed: Peng, C, 2011-08-24 has a Stoichiometric coefficient of 2