MEF2 proteins phospho-p38 alpha/beta/gamma MAPK phospho p38:phospho MEF2 Phosphorylation of MEF2 proteins by p38 Authored: Garapati, P V, 2008-08-11 10:36:48 EC Number: 2.7.11 Edited: Garapati, P V, 2008-08-11 10:36:48 Pubmed10330143 Pubmed10805738 Pubmed9069290 Pubmed9858528 Pubmed9988769 Reactome Database ID Release 43448955 Reactome, http://www.reactome.org ReactomeREACT_21276 Reviewed: Krauss, RS, 2010-02-09 The family of transcription factors myocyte enhancer factor-2 (MEF2) regulate myogenesis through combinatorial interactions with other transcription factors to the MEF2 site found in the promoter regions of numerous muscle specific genes. There are four members of the MEF2 family, MEF2A to D.<br>p38 MAPK plays a role in the regulation of the MEF2 family members and this is mediated by the phosphorylation of two or three (Thr312 and 319 in MEF2A and Thr 293, 300 and ser387 in MEF2C) amino acids in the C-terminal activation domain of MEF2 factors. MEF2A and MEF2C are preferred substrates for p38 compared with MEF2B and MEF2D. The phosphorylation of MEF2 members results in their increased transcriptional activity. has a Stoichiometric coefficient of 5