phospho-MEF2 proteins Myod:phospho-E heterodimers MyoD:phospho-E:phospho MEF2 Interaction of MyoD:E protein with MEF2 Authored: Garapati, P V, 2008-08-11 10:36:48 Edited: Garapati, P V, 2008-08-11 10:36:48 MyoD-E protein heterodimers interact with MEF2 proteins to synergistically activate myogenesis. This interaction occurs via association of these two heterologous classes of transcription factors through their DNA-binding and dimerization motifs. The combinatorial associations of these two protein families appear to establish a transcriptional code specific for skeletal muscle gene activation. Together with the Mef2 proteins and E proteins, MyoD transcription factors are responsible for coordinating muscle-specific gene expression in the undifferentiated myoblast. MyoD activation leads to expression of myogenin, M-cadherin, myosin heavy and light chains, and muscle creatine kinase. Pubmed9418854 Reactome Database ID Release 43448963 Reactome, http://www.reactome.org ReactomeREACT_21369 Reviewed: Krauss, RS, 2010-02-09