Cleavage of NODAL Proprotein Authored: May, B, 2011-01-23 EC Number: 3.4.21 Edited: May, B, 2011-01-23 Either FURIN or PACE4 endoproteases cleave the 321 amino acid NODAL proprotein to yield the 110 amino acid NODAL mature protein. In cultured mouse cells the CRIPTO coreceptor at the plasma membrane recruits both NODAL proprotein and FURIN or PACE4 endoprotease. Reactome Database ID Release 431181152 Reactome, http://www.reactome.org ReactomeREACT_111228 Reviewed: Peng, C, 2011-08-24