NODAL Receptor NODAL Ligands (Agonists) NODAL Ligand:NODAL Receptor The NODAL Receptor Binds NODAL Ligands Authored: May, B, 2011-01-23 Edited: May, B, 2011-01-23 NODAL binds a receptor comprising a type I activin receptor (ACVR1B or ACVR1C), a type II activin receptor (ACVR2 or ACVR2B), and a EGF-CFC coreceptor (CRIPTO or CRYPTIC). Though NODAL is able to signal via the ACVR1C (ALK7) receptor (Reissman et al. 2001), experiments in mouse indicate NODAL signaling via ALK7 is dispensable during embryogenesis (Jornvall et al. 2004). Pubmed15150278 Pubmed15485907 Pubmed15531507 Pubmed21229555 Pubmed21356369 Reactome Database ID Release 431181155 Reactome, http://www.reactome.org ReactomeREACT_111250 Reviewed: Peng, C, 2011-08-24