PathwayStep4698 PathwayStep4697 Free APC/C phosphorylated by Cyclin B:Cdc2 Free APC/C phosphorylated by Plk1 Phosphorylation of the APC/C GENE ONTOLOGYGO:0051437 Phosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation in vivo have not been determined with certainty, both Plk1 and Cyclin B:Cdc2 have been implicated in this process. Pubmed10793135 Reactome Database ID Release 43176412 Reactome, http://www.reactome.org ReactomeREACT_6904 Reviewed: Peters, JM, 2006-03-27 22:55:09