PathwayStep4705 PathwayStep4704 PathwayStep4700 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 APC/C:Cdc20 mediated degradation of mitotic proteins Following phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the mitotic cyclins (Cyclin A and Cyclin B) as well as the protein securin which functions in sister chromatid cohesion. Timely degradation of these proteins is essential for sister chromatid separation and the proper timing of exit from mitosis (See Zachariae and Nasmyth, 1999). Cdc20 is degraded late in mitosis (Reviewed in Owens and Hoyt, 2005) Pubmed10465783 Pubmed15949434 Reactome Database ID Release 43176409 Reactome, http://www.reactome.org ReactomeREACT_6781 Reviewed: Peters, JM, 2006-03-27 22:55:09 APC/C:Cdc20 mediated degradation of Cyclin B APC/C:Cdc20 mediated degradation of Securin