PathwayStep4664 PathwayStep4666 PathwayStep4665 Degradation of multiubiquitinated Securin Association of Securin with Cdc20:APC/C complex Ubiquitination of Securin by phospho-APC/C:Cdc20 complex APC/C:Cdc20 mediated degradation of Securin Authored: Lorca, T, Castro, A, 2006-01-26 00:00:00 Edited: Matthews, L, 2006-01-30 00:00:00 GENE ONTOLOGYGO:0031145 Pubmed10827941 Pubmed12070128 Reactome Database ID Release 43174154 Reactome, http://www.reactome.org ReactomeREACT_6871 Reviewed: Peters, JM, 2006-03-27 22:55:09 The separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohesin subunit, Scc1 that is responsible for the cohesion of sister chromatids (reviewed in Nasmyth et al., 2000). Securin destruction begins at metaphase after the mitotic spindle checkpoint has been satisfied (Hagting et al., 2002).