PathwayStep4629 PathwayStep4608 PathwayStep4611 PathwayStep4615 G2/M Transition Cyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of T14 and Y15. Cyclin A, B - Cdc2 complexes phosphorylate several proteins involved in mitotic spindle structure and function, the breakdown of the nuclear envelope, and topological changes in chromosomes allowing resolution of their entanglement and condensation that is necessary for the ~2 meters of DNA to be segregated at mitosis. GENE ONTOLOGYGO:0000086 Reactome Database ID Release 4369275 Reactome, http://www.reactome.org ReactomeREACT_2203 Reviewed: Lorca, T, 2005-10-10 00:00:00 Cyclin A/B1 associated events during G2/M transition Cyclin B2 mediated events Polo-like kinase mediated events Centrosome maturation