PathwayStep4602 PathwayStep4601 PathwayStep4600 PathwayStep4606 PathwayStep4605 PathwayStep4604 PathwayStep4603 PathwayStep4607 Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes PathwayStep4599 PathwayStep4592 PathwayStep4591 PathwayStep4593 PathwayStep4596 PathwayStep4598 PathwayStep4597 PathwayStep4590 PathwayStep4588 PathwayStep4589 PathwayStep4587 PathwayStep4478 PathwayStep4481 Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm Translocation of Cdc25B to the cytoplasm Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes Translocation of Cdc25 to the nucleus Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes Phosphorylation of Cyclin B1 in the CRS domain Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases Formation of Cyclin A:Cdc2 complexes Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus Myt-1 mediated phosphorylation of Cyclin A:Cdc2 Formation of Cyclin B:Cdc2 complexes CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes Translocation of active Cdc25C to the nucleus Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes Cyclin A/B1 associated events during G2/M transition Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases. The G2/M transition is regulated through the phosphorylation of nuclear lamins and histones (reviewed in Sefton, 2001). Pubmed18228324 Reactome Database ID Release 4369273 Reactome, http://www.reactome.org ReactomeREACT_1857 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes