PathwayStep4573 PathwayStep4574 PathwayStep4575 PathwayStep4571 PathwayStep4572 Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta Relocalization of nuclearly localized Cyclin D1 to the cytoplasm Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm Ubiquitination of Cyclin D1 Proteasome mediated degradation of Cyclin D1 Ubiquitin-dependent degradation of Cyclin D1 After the Cyclin D serves the role of mediating reactions by Cdk4 and Cdk6, it is shuttled to the cytoplasm and degraded in a ubiquitin-dependent manner. Whether Cdk4 and Cdk6 are truly redundant is a topic still under investigation, although both the kinases are required for normal cell cycle progression.<p>Destruction of the D type cyclins accompanies the end of the G1 phase, and the E type cyclins are involved in transition of the cell from G1 to S phase. Reactome Database ID Release 4369229 Reactome, http://www.reactome.org ReactomeREACT_4