PathwayStep4621 PathwayStep4622 PathwayStep4617 PathwayStep4616 Recruitment of Plk1 to centrosomes Recruitment of CDK11p58 to the centrosomes Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome Recruitment of mitotic centrosome proteins and complexes Authored: Matthews, L, 2008-11-11 14:53:40 Edited: Matthews, L, 2008-11-09 05:12:41 Pubmed17178454 Pubmed18437411 Reactome Database ID Release 43380270 Reactome, http://www.reactome.org ReactomeREACT_15296 Reviewed: Merdes, A, 2008-11-17 13:55:29 The mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centrosomes recruiting additional gamma TuRC complexes and acquiring mitosis-associated centrosomal proteins including NuMA, Plk1 and CDK11p58 (reviewed in Schatten 2008; Raynaud-Messina and Merdes 2007). Recruitment of NuMA to mitotic centrosomes