DSCAM binds Netrin-1 DSCAM binds DCC DSCAM/DSCAML1 homodimerization Activation of JNK by DSCAM DSCAM associates with Rac1-GTP:pPAK1 Activation of p38MAPK by DSCAM PathwayStep4830 PathwayStep4831 PathwayStep4826 PathwayStep4827 PathwayStep4828 PathwayStep4829 DSCAM interactions Authored: Garapati, P V, 2010-01-05 DSCAM (Down syndrome cell adhesion molecule) is one of the members of the Ig superfamily CAMs with a domain architecture comprising 10 Ig domains, 6 fibronectin type III (FN) repeats, a single transmembrane and a C terminal cytoplasmic domain. DSCAM is implicated in Down syndrome (DS) due to the chromosomal location of the DSCAM gene, but no evidence supports a direct involvement of DSCAM with DS. It likely functions as a cell surface receptor mediating axon pathfinding. Besides these important implications, little is known about the physiological function or the molecular mechanism of DSCAM signal transduction in mammalian systems. A closely related DSCAM paralogue Down syndrome cell adhesion moleculelike protein 1 (DSCAML1) is present in humans. Both these proteins are involved in homophilic intercellular interactions. Edited: Garapati, P V, 2010-01-05 Pubmed10925149 Pubmed18585357 Reactome Database ID Release 43376172 Reactome, http://www.reactome.org ReactomeREACT_25299 Reviewed: Clemens, JC, 2010-08-10