Na+/H+ exchanger transport (at cell membrane) Na+/H+ exchanger transport (at early endosome membrane) Na+/H+ exchanger transport (at trans-golgi membrane) Na+/H+ exchanger transport (at late endosome membrane) PathwayStep4870 PathwayStep4871 PathwayStep4868 PathwayStep4869 Sodium/Proton exchangers Authored: Jassal, B, 2009-06-11 Edited: Jassal, B, 2009-06-11 Pubmed11279194 Pubmed12845533 Pubmed15522866 Reactome Database ID Release 43425986 Reactome, http://www.reactome.org ReactomeREACT_19314 Reviewed: He, L, 2009-08-24 The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.