ABCA4 mediates atRAL transport The ABCC family mediates organic anion transport ABCA8, B1 and B5 mediate xenobiotic efflux HCO3- transport through ion channel PathwayStep4853 PathwayStep4858 PathwayStep4859 PathwayStep4856 PathwayStep4857 PathwayStep4846 ABCA transporters in lipid homeostasis ABC-family proteins mediated transport Authored: Gopinathrao, G, 2008-11-23 14:00:06 Edited: Gopinathrao, G, 2008-11-29 15:54:33 GENE ONTOLOGYGO:0055085 Pubmed11435397 Pubmed12045106 Pubmed15209530 Pubmed19234479 Reactome Database ID Release 43382556 Reactome, http://www.reactome.org ReactomeREACT_15480 Reviewed: D'Eustachio, P, 2011-08-23 Reviewed: Matthews, L, 2008-12-02 15:41:53 The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. These substrates include amino acids, lipids, inorganic ions, peptides, saccharides, peptides for antigen presentation, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the cell, but are also involved in intracellular compartmental transport. Energy derived from the hydrolysis of ATP is used to transport the substrate across the membrane against a concentration gradient. Human genome contains 48 ABC genes; 16 of these have a known function and 14 are associated with a defined human disease (Dean et al. 2001, Borst and Elferink 2002, Rees et al. 2009). Mitochondrial ABC transporters