PathwayStep898 PathwayStep861 PathwayStep862 PathwayStep865 PathwayStep852 PathwayStep849 PathwayStep4885 PathwayStep4880 PathwayStep4876 PathwayStep4872 PathwayStep4867 PathwayStep4864 Proton-coupled neutral amino acid transporters Amino acid transport across the plasma membrane Proton/oligonucleotide cotransporters Organic anion transporters Sodium/Proton exchangers Sodium/Calcium exchangers Bicarbonate transporters Transport of inorganic cations/anions and amino acids/oligopeptides Authored: Jassal, B, 2009-06-04 Edited: Jassal, B, 2009-06-04 GENE ONTOLOGYGO:0006811 Pubmed12734757 Pubmed12739168 Pubmed12759754 Pubmed12845533 Pubmed16461757 Pubmed16955105 Pubmed17581921 Pubmed17693766 Pubmed18195086 Pubmed18400693 Pubmed18690016 Pubmed19164095 Reactome Database ID Release 43425393 Reactome, http://www.reactome.org ReactomeREACT_19397 Reviewed: He, L, 2009-08-24 Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl–-dependent transport of basic anions [e.g. HCO3–, (CO3)2–] in various tissues and cell types (in addition to pH regulation, specific members of this family also contribute to vectorial trans-epithelial base transport in several organ systems including the kidney, pancreas, and eye) (Pushkin A and Kurtz I, 2006); SLC8 is a group of Na+/Ca2+ exchangers (SLC8A1 is involved in cardiac contractility) (Quednau BD et al, 2004); SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers (Altimimi HF and Schnetkamp PP, 2007); SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons (Orlowski J and Grinstein S, 2004); SLC12 functions as Na+, K+ and Cl– ion electroneutral symporters (Hebert SC et al, 2004); SLC26 is the trans-epithelial multifunctional anion (e.g. sulfate, oxalate, HCO3–, Cl–) exchanger family, important in cartilage development, production of thyroid hormone, sound amplification in the cochlea etc (Sindic A et al, 2007; Dorwart MR et al, 2008; Ashmore J, 2008). SLC34 is an important Type II Na+/(HPO4)2– symporter (Forster IC et al, 2006; Virkki LV et al, 2007); SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/(H2PO4)– symporter (Collins JF et al, 2004; Virkki LV et al, 2007). Eight SLC gene families are involved in the transport of amino acids and oligopeptides. Multifunctional anion exchangers Sodium-coupled phosphate cotransporters Cation-coupled Chloride cotransporters Vesicular inhibitory amino acid transport Glutamate transport