PathwayStep4744 PathwayStep4753 PathwayStep4754 PathwayStep4739 Disassociation of Processive Complex and Completed Telomere End Telomere C-strand (Lagging Strand) Synthesis Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08 Due to the antiparallel nature of DNA, DNA polymerization is unidirectional, and one strand is synthesized discontinuously. This strand is called the lagging strand. Although the polymerase switching on the lagging strand is very similar to that on the leading strand, the processive synthesis on the two strands proceeds quite differently. Short DNA fragments, about 100 bases long, called Okazaki fragments are synthesized on the RNA-DNA primers first. Strand-displacement synthesis occurs, whereby the primer-containing 5'-terminus of the adjacent Okazaki fragment is folded into a single-stranded flap structure. This flap structure is removed by endonucleases, and the adjacent Okazaki fragments are joined by DNA ligase. GENE ONTOLOGYGO:0032201 Pubmed15189140 Reactome Database ID Release 43174417 Reactome, http://www.reactome.org ReactomeREACT_7961 Reviewed: Price, C, 2006-07-13 18:33:38 Processive synthesis on the C-strand of the telomere Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation